Kansas City Chiefs vs Indianapolis Colts: Picks & Analysis 9/25/2022

Kansas City Chiefs vs Indianapolis Colts: Picks & Analysis 9/25/2022

September 22, 2022



Game Preview


The Kansas City Chiefs and the Indianapolis Colts meet Sunday in NFL action at Lucas Oil Stadium. Kansas City is 2-0 so far this year and coming off a close win over the Chargers. As for the Colts, they’re 0-1-1 on the young season, falling to the Jaguars in their last game.


Kansas City had a solid opening game to kick off the 2022 season, beating the Cardinals 44-21 and scoring in every quarter along the way. QB Patrick Mahomes threw for 360 yards and five touchdowns, while Isiah Pacheco led the rush on 62 yards and a score.


In game two the Chiefs played a much tighter game but the outcome was still the same. Kansas City scored 13 points in the fourth quarter versus the Chargers to pull out the 27-24 win. Mahomes managed 235 yards and two scores on 24-of-35 passing in that one.


Kansas City was fortunate to get the win over the Chargers, giving up 401 total yards to LA along with 5.4 yards per play and 21 first downs. The Chiefs were a sketchy 4-of-12 on third-down tries and produced just 15 first downs, but still got the win. There’s room for improvement but overall the offense hasn’t been too bad so far.


Over on the Colts’ side, they kicked off the year against the Texans in a wild game. Indianapolis came back from a 20-3 fourth-quarter deficit and eventually earned the tie. Quarterback Matt Ryan posted 352 yards with one touchdown and one interception on 32-of-50 passing.


Game two didn’t go very well for the Colts. They took on their division rival Jaguars and were down 17-0 at the half in an eventual 24-0 blowout loss. Ryan threw for 195 yards and three picks in the loss, and Jonathan Taylor led the rush with 54 yards on nine carries.


Let’s check the latest NFL picks, news, stats and NFL expert picks for Chiefs vs Colts. We’ve plenty of NFL predictions for you to consider.


Kansas City Chiefs vs Indianapolis Colts Game Information


  • Date: 09/25/2022
  • Time: 01:00 PM ET
  • Location: Lucas Oil StadiumIndianapolis,IN
  • How to Watch Chiefs vs Colts: NBC
  • Live Stream: NFL.TV


Chiefs vs Colts Betting Lines


Colts are +225 according to our Vegas NFL Lines. This means that if you wager $100 you have the chance to win $225. On the other side, Chiefs are –265 according to the Vegas NFL Lines. This means that if you wager $100 you have the chance to win $37.74.

The implied probability for these two teams attached to the betting lines have Colts at a 30.77% chance of winning the game, meanwhile, Chiefs have 72.60% probability of finishing the game with the W.


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